Considering that one Ghostbuster died recently and Bill Murray is busy creating viral moments, I think any chance of Ghostbusters III becoming a reality is about as realistic as... Ghostbusters III becoming a reality.
But IF it did happen and IF it was directed by Quentin Tarintino and IF it was shot in claymation, it might look like this...
Source: lee hardcastle
Well, that was bizarrely awesome. Who ya gonna call? The Wolf, that's who you're gonna call.