Comedian Steve Hofstetter (who's a former CollegeHumor contributor!) was going through a pretty common wisdom thing - having a kid isn't something special or difficult - when a parent in the crowd decided to do the ONE THING you're not supposed to do at a stand-up show and loudly yell back at the comedian. She was a little offended by the idea that it was easier to have a kid than it is to order a pizza.
The heckler's response to this already perfect burn was, naturally, to keep going - by asking Mr. Hofstetter if HE had any children. He told her that he didn't have any, so she responded that he couldn't POSSIBLY know anything about kids then.
Bad move, lady.
He even went to the trouble to summarize his point in a way that everyone could understand (if the helicopter thing didn't already make it blindingly obvious):
And just to drive it home one last time, he asked the heckler if she was a sports fan. She responded she was - for the Washington Redskins in particular. He asked if she ever got mad (or "upset") when the Redskins lost, and followed it by: